Turmeric: Miracle Weapon Against Diabetes, It Works

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Diabetes is a chronic metabolic condition in which blood sugar levels in the body remain high as the agency failed to control it. Insulin is a hormone that plays an important role in this disease. It is produced by the pancreas and blood sugar control. blood sugar or glucose acts as fuel for a variety of cellular activity. Insulin moves glucose from the blood into muscle, fat and liver cells where it is stored or used as fuel. In diabetes did little insulin or insulin resistance glucose inhibits this transformation and so are likely to negatively affect the body. There are three main types of diabetes:

    Type 1 diabetes: This is caused by lack of insulin production.
    Diabetes Type 2: This is caused by the failure of cells to respond to insulin appropriately.
    Gestational diabetes: This occurs during pregnancy due to high glucose levels.

Type 1 diabetes can not be treated as Type 2 can be treated with the use of drugs with or without insulin and lifestyle changes. Turmeric is a perennial herb that grows mainly in Asia as a spice. many research studies have proven the use of turmeric in treating diabetes and its complications. This article is going to the top of the range of research and development conducted in the medical use features turmeric to cure or prevent pathological conditions associated with diabetes.
Turmeric composition

Bioactive properties of turmeric is due to the various components isolated from the rhizome. Important components are curcuminoids and erratic oil. Curcuminoids consisting of curcumin, monodemethoxycurcumin and bisdemethoxycurcumin. They are natural antioxidants and gives a yellow color to the powder. Erratic oil containing aromatics (benzene ring-containing) compounds where tumerone and ar-tumerone is considered medically rather important. Curcumin from turmeric contribute 5 to 6.6% while the volatile oils make up less than 3.5% of the composition. Sugar, protein and resin are also isolated from the rhizomes.
The role of turmeric in treating Diabetes

In this section we will understand the basic mechanisms which turmeric medical use features in treating diabetes and after that we will go to the special case of the mechanism of action.
Inflammation in Diabetes & Turmeric

The mechanisms involved in the pathogenesis of inflammation that causes diabetes is complex. Type 1 diabetes is an immune mediated disease in which cells of the pancreas elected destroyed. It occurs when cells of the pancreas that produce insulin are being attacked by cells of the immune system and the condition is called insulitis. Infiltration of immune cells causing the secretion of pro-inflammatory cytokines such as IL-1, as well as facilitating the progress of inflammation and cause cell death.

Chronic low-level inflammation associated with obesity and diabetes. A pro-inflammatory cytokine called tumor necrosis factor-α is overproduced in human adipose tissue obesity. This excess is known to affect the function of insulin and contribute to insulin resistance. The function of macrophages (a type of immune cells) and adipocytes (fat cells) that overlap. Thus, it appears that the macrophages in adipose tissue, either alone or with the help of adipocytes, secrete proteins that accelerate inflammation and contribute to insulin resistance. Password biochemistry also contribute to inflammation is involved in diabetes. IL-1beta, TNF-α and IL-6 is a pro-inflammatory agent that is involved in the pathogenesis of major type 2 diabetes.

Turmeric shows anti-inflammatory properties by modulating a variety of routes and activities of many proteins. Some of the mechanisms involved are:

    The suppression of nuclear factor-kappa B and with the downregulation of COX-2 activity
    Inhibition of the production of inflammatory cytokines such as TNF-α, IL-6, IL-1beta
    Reducing the activity of enzymes and proteins that mediate inflammation

These mechanisms find their use in combating inflammation caused by diabetes and prevent the increase in number.

Oxidative Stress in Diabetes & Turmeric

Oxidative stress plays a major role in the pathogenesis of diabetes. Oxidative stress is a loss of balance between the body's natural antioxidant defenses and production of reactive oxygen species. Reactive oxygen species (ROS) are chemically reactive molecules containing oxygen and carry a phenomenon essential for normal cell function. However, in poor condition, ROS levels rise dramatically and cause cell death and inflammation.

In diabetes there was increased consumption of glucose by the cells of the endothelium (the inner lining of blood vessels) in adipose tissue (body fat). Under hyperglycemic (high blood sugar levels) conditions increases glucose intake causes excessive production of ROS causes oxidative degradation of fats (lipids), oxidative damage to cells and initial password inflammation. Turmeric, an antioxidant that is well-known, scavenges ROS, preventing lipid oxidation and increase the level of antioxidant enzymes. These properties of turmeric may help reduce oxidative stress observed in diabetes.
Turmeric & Common symptoms of Diabetes

Several research studies have confirmed the effectiveness of turmeric in treating the symptoms associated with diabetes. One remarkable property of turmeric that has been exploited for this purpose is the ability to reduce blood sugar. So he suggested that diabetic patients had used drugs for the treatment of hyperglycemia should avoid food additives turmeric. The second action of drugs can reduce the level of sugar in the blood greatly and cause complications. Other symptoms such as high levels of fat, increased thirst and frequent urination can also be treated with turmeric.

research 1

A study conducted in Japan to evaluate the effects of turmeric on hyperglycemia. Genetically diabetic mice had been given alcohol extract of turmeric and a decrease in blood glucose levels. The main constituents of the extract is curcumin, demethoxycurcumin, bisdemethoxycurcumin and ar-tumerone. This review is divided into two: an experiment in animal and laboratory experiments. Animals were divided into two groups: one meal with a diet without the extract of saffron (the control group) and others with turmeric extract. The blood sugar level was found to be increased in the control group while they were coupled with turmeric has the same glucose levels as measured before eating. This suggests that turmeric, as a functional food ingredient, is useful in preventing or reducing type 2 diabetes.

Laboratory experiments showed that the PPAR-gamma activation turmeric involved. This is a receptor that is involved in the differentiation of fat cells and the usual targets for drugs anti-diabetes. Activation of this receptor reduce insulin resistance by increasing the number of small adipocytes normal and causes normal cell death serves large adipocytes. Turmeric binds with these receptors is a suggested mechanism for the decrease in blood glucose levels.

research 2

diabetic dyslipidemia is a condition that is common in diabetes that increase the risk of heart disease and stroke. Dyslipidemia refers to the level of abnormal blood lipids (fats and related compounds). It is caused by insulin resistance and the function of the enzyme lipoprotein lipase unnatural. high lipid levels in the blood can lead to the risk of atherosclerosis - clogged arteries with fat and other ingredients.

Studies conducted in the Central Food Technological Research Institute, Mysore, India showed that the curcumin diet can lower high lipid levels in diabetic animals. Drug induced diabetic mice were given 0.5% curcumin additional dining for 8 weeks and it has been noted that blood cholesterol levels dropped significantly. It also looks at the effects of curcumin diabetic animals maintained on a high cholesterol diet, showed that curcumin is effective in dealing with a very high lipid levels. A decrease in the fraction of lipid in the liver and kidneys note. This study shows that these actions hypolipidemic (reduced lipid levels) turmeric is caused by increased activity of cholesterol 7 alpha-hydroxylase. Upregulation of this enzyme is known to reduce cholesterol levels in the cells.
Turmeric as a precaution against Type 2 diabetes

Type 2 diabetes is said to be controlled with lifestyle changes and diet. This step continues potentiated by the addition of turmeric and the following research confirm this fact.

In one study conducted in the prediabetic population (people who have a tendency to develop diabetes in the near future), the effects of curcumin in slowing the development of diabetes noticed. Individuals 35 years and above have been included in this study. Two randomized groups have been created: one treated with curcumin, the other with a placebo. They were asked to take 6 capsules a day for nine months. Each capsule contains 250 mg of curcumin has kurkuminoid. Various physiological parameters were measured before treatment and at intervals of 3, 6 and 9 months of treatment.

Many of the subjects in the placebo-treated group developed diabetes while none of the subjects were treated with curcumin developed diabetes. homeostatic model evaluation is a method used to determine insulin resistance and the function of the cells that produce insulin in units that can be measured. HOMA-IR represents Homa insulin resistance while beta-cell function shows. Increased levels of HOMA-beta and reduce the level of HOMA-IR in curcumin treated group reinforces the idea of ​​turmeric as an anti-diabetic drug. Also increased levels of adiponectin, an anti-inflammatory agent, views. Based on research of 9 months, she has suggested that curcumin extract may be used to prevent diabetes in the prediabetic population.
Turmeric and complications associated with Diabetes

All types of diabetes raises the risk of developing complications but these are generally developed after 10-20 years from the beginning of the disease. Complications caused damage to the blood vessels. Stroke and cardiovascular disease is macrovascular (large blood vessels) The main diseases that occur. Between microvascular (blood vessel) disease, kidney damage, nerve and eye views. Features medicine turmeric has been used even in treating such complications.

Review 1: Turmeric & Vascular Dysfunction

vascular dysfunction is a condition that develops early after the onset of diabetes is not managed properly. Inner ling damaged blood vessels and the resulting imbalance between the materials is responsible for working with blood vessels. This imbalance is caused by high blood glucose levels. Permeability of blood vessels affected and impaired blood flow increases the risk of atherosclerosis.

Studies conducted in Thailand assessed the effects of curcumin on diabetes caused by vascular dysfunction. Five groups of rats have been created in which the two groups, in which diabetes has been boosted, given curcumin at a dose of 30mg / kg and 300mg / kg. Various enzymes and proteins whose levels increased in the case of vascular dysfunction measured. After 6 weeks of treatment curcumin appears that all measured parameters increased in the control group but not in curcumin treated group. Curcumin is found to inhibit the upregulation of this protein and is caused by anti-inflammatory activity of curcumin. The results showed that curcumin can weaken diabetes caused by vascular dysfunction.

Review 2: Turmeric & Diabetic nephropathy

diabetic nephropathy is a complication of diabetes of long standing in which the kidneys are damaged. It is characterized by loss of kidney function and increased excretion of protein in the urine. Inflammation of the kidney was observed which led to the migration of immune cells into the kidney. Subsequent immune cells secrete enzymes and proteins (proinflammatory mediators) that causes the disease to progress.

One study evaluated the effects of oral supplementation of turmeric against diabetic nephropathy. 40 patients with type 2 diabetes have been divided into two groups of 20 people each one. The experimental group received 3 capsules 500mg turmeric while the control group received the same capsules that contain starch. A significant decrease in the levels of inflammatory mediators seen in curcumin treated groups when values ​​before and after treatment were compared. Also the reduction in urinary protein excretion observed, suggesting a therapeutic role in diabetic nephropathy turmeric.

Dosage

Turmeric proved useful in diabetes in a dose-dependent manner: the higher dose more positive effect. However, the suggested dosage should strictly followed to avoid adverse effects. The recommended daily dose limits for various forms of turmeric is as follows:

    Cut 1.5-3g roots- day
    Roots- powder 1-3g per day
    Uniform powder 400-600mg three times a day
    liquid extract (1: 1) - 30-90 drops a day
    Wall (1: 2) - 15-30 drops 4 times a day

For more information about the dose, check out this article.
Vigilance

Turmeric supplements are formulated as a direct source of curcumin or contain ingredients that increase their absorption in the body. If not taken according to the recommended doses, these supplements can be a side effect. Turmeric is known to reduce blood glucose levels. So it should be avoided with diabetes medications that treat hyperglycemia, because together they can lower glucose levels drastically. Therefore, blood thinning activity, turmeric supplements must be stopped before surgery. They should also be avoided in the case of pregnancy and lactation. Turmeric is known to interfere with the activity of drugs that reduce stomach acid. If the rocks or obstacles in the passage of bile, turmeric should be taken with caution.
conclusion

An estimated 387 million people suffer from diabetes worldwide in 2014 and is expected to increase to 592 million by 2035. Type 2 diabetes accounts for 90% of the cases. Global economic burden caused by diabetes in 2014 was estimated at $ 612 billion USD. Turmeric is an anti-diabetic agent proven. This article covers only a few studies were selected from innumerous research that explores the effects of turmeric in various aspects diabetes.It is clear that turmeric may play a role in the prevention of diabetes and also help people with diabetes.